Which symptoms are observed in the secondary stage of syphilis?

The secondary stage of syphilis is characterized by systemic manifestations due to the dissemination of the Treponema pallidum bacteria throughout the body. Fever and a rash that particularly affects the palmar and plantar surfaces are hallmark symptoms seen during this stage. The rash in secondary syphilis can also appear on other parts of the body and may present as reddish-brown spots or lesions.

The fever often accompanies the rash, indicating an inflammatory response to the infection. This stage can also present with mucous membrane lesions known as mucous membrane pemphigus or condylomata lata, but the distinct feature of having a rash on the palms and soles sets this stage apart.

The other symptoms, while they may occur in various contexts, are not defining characteristics of the secondary stage of syphilis. For instance, swollen lymph nodes are generally part of the primary stage and may contribute to some systemic effects, but they lack the specificity of the palmar and plantar rash. Headaches and weight loss can occur in different infections or illnesses but are not recognized as classic symptoms of secondary syphilis. The option that suggests the condition is asymptomatic does not apply as secondary syphilis is known for its overt symptoms.