Which substance may exacerbate the effects of antihypertensives?

Niacin, also known as vitamin B3, can exacerbate the effects of antihypertensive medications due to its ability to cause vasodilation. This vasodilatory effect can lead to a decrease in blood pressure, which, when combined with antihypertensive agents, may result in hypotension or an exaggerated decrease in blood pressure.

Niacin works by enhancing the levels of high-density lipoprotein (HDL) cholesterol and lowering triglycerides, but it can also cause flushing and increased blood flow. When a patient is on antihypertensive therapy, the additive effects of niacin could potentiate the response to these medications, leading to adverse effects like dizziness and lightheadedness due to hypotension.

In contrast, substances like aspirin, insulin, and metformin do not typically have the same effects on blood pressure regulation that niacin does. Aspirin is mostly used for its antiplatelet effects and does not significantly influence blood pressure management in the same way. Insulin and metformin are used in the management of diabetes and do not inherently affect blood pressure or its regulation when used concurrently with antihypertensive medications. Understanding the interactions and effects of various substances on blood pressure is crucial for safe medication management in patients with hypertension