Which serological markers indicate active Hepatitis B infection?

The presence of serological markers indicating active Hepatitis B infection is characterized by specific antibodies and antigens in the clinical assessment. The correct answer identifies HBsAg, HBeAg, Anti-HBc, and IgM as key markers of an active infection.

HBsAg (Hepatitis B surface Antigen) is the principal marker for indicating an ongoing Hepatitis B virus (HBV) infection. Its presence suggests that the virus is actively replicating in the patient's body.

HBeAg (Hepatitis B e Antigen) further suggests active viral replication and is associated with high levels of infectiousness. Its presence indicates that the virus is not only present but also actively replicating, which increases the risk of transmission.

Anti-HBc (Antibody to Hepatitis B core Antigen) is also a crucial indicator of Hepatitis B infection. If it is the IgM form of this antibody, it signifies a recent or acute infection. Elevated levels of IgM Anti-HBc are frequently seen during the initial phase of an infection, thus suggesting active disease.

Furthermore, the combination of these markers confirms that the infection is not only present but also active, helping healthcare providers make informed decisions regarding patient management and potential treatment options. The