Which of the following is NOT a sign of hepatotoxicity?

Hyperglycemia is not considered a sign of hepatotoxicity. Hepatotoxicity refers to liver damage resulting from exposure to drugs, chemicals, or other factors which can lead to an increase in liver enzymes and the manifestation of conditions directly related to liver dysfunction.

Jaundice, characterized by yellowing of the skin and eyes, occurs when there is an accumulation of bilirubin in the bloodstream, commonly due to liver damage and impaired detoxification processes. Prolonged prothrombin time (PT) reflects liver dysfunction, as the liver synthesizes clotting factors, and any impairment can lead to an inability to produce these factors adequately, resulting in longer clotting times. Elevated liver function tests (LFTs), such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), indicate liver injury or inflammation, which are hallmark signs of hepatotoxicity.

In contrast, hyperglycemia can occur due to various reasons unrelated to direct liver injury or dysfunction; it may arise from stress or metabolic conditions like diabetes. Therefore, while the other signs are specifically indicative of liver impairment, hyperglycemia does not specifically relate to hepatotoxicity.