Which of the following is a treatment option for closed angle glaucoma?

Acetazolamide is a carbonic anhydrase inhibitor that decreases intraocular pressure by reducing the production of aqueous humor, making it an effective treatment for closed-angle glaucoma. This condition is characterized by a sudden increase in intraocular pressure due to the blockage of the drainage angle of the eye, and acetazolamide can help to rapidly lower that pressure, alleviating the acute symptoms and reducing the risk of optic nerve damage.

While other medications like timolol, a beta-blocker, can be used to manage intraocular pressure in various forms of glaucoma, they do not provide the same rapid effect as acetazolamide in an acute setting. Brimonidine, an alpha agonist, can also help in treating glaucoma, primarily by decreasing aqueous humor production, but again, it is not the first-line option in acute situations where immediate pressure reduction is critical. Pilocarpine, a cholinergic agent, works by constricting the pupil and facilitating aqueous humor drainage, but it is typically not effective in an acute angle-closure crisis where a rapid intervention is necessary. Therefore, acetazolamide is the most appropriate choice for immediate treatment of closed-angle glaucoma.