Which of the following is NOT a sign of salicylate intoxication?

Jaundice is not a sign of salicylate intoxication, which is primarily characterized by a range of other systemic effects due to salicylate's pharmacological action and its metabolism. Salicylate intoxication can lead to metabolic acidosis, respiratory alkalosis, and CNS effects, which include symptoms like dehydration from sweating, hyperthermia due to increased metabolic activity, and tinnitus, which is commonly reported by individuals who have ingested excessive salicylate.

Dehydration occurs as a complication due to the potential for hyperventilation, fever, and increased metabolic demands leading to fluid loss. Hyperthermia can arise as a result of increased cellular metabolism and the body's impaired ability to regulate temperature in the context of drug toxicity. Tinnitus, or ringing in the ears, is also a classic symptom of salicylate poisoning, resulting from direct effects on the cochlear function.

In contrast, jaundice is associated with liver dysfunction or hemolysis, which is not a typical finding in salicylate toxicity. Thus, its presence would be suggestive of other underlying conditions, such as acute liver injury or biliary obstruction, rather than specifically salicylate intoxication.