Which medications are known to potentially worsen symptoms of BPH?

Selective serotonin reuptake inhibitors (SSRIs) can potentially worsen symptoms of benign prostatic hyperplasia (BPH) due to their possible effects on sexual function and urinary tract symptoms. These medications can lead to increased urinary retention or changes in bladder function, complicating BPH symptoms. The mechanism is not fully understood but may relate to the impact of SSRIs on serotonin pathways, which can influence bladder control and prostate function.

For context, while diuretics can increase urinary frequency and urgency due to their role in promoting urine production, they do not inherently worsen BPH symptoms. Beta-blockers are typically not associated with exacerbating BPH, as they do not have direct effects on prostate tissue or bladder function. NSAIDs may not directly affect BPH symptoms either, although they can influence urinary outcomes due to their effects on kidney function or fluid balance.

Understanding the unique interactions of different classes of medications with BPH is essential for managing patients effectively, especially in those with existing urinary symptoms.