Which inflammatory condition primarily affects patients over the age of 50?

Giant Cell Arteritis, also known as temporal arteritis, is an inflammatory condition that primarily affects older adults, particularly those over the age of 50. This condition involves the inflammation of the blood vessels, particularly the temporal arteries, and it can lead to serious complications such as vision loss if not treated promptly.

The onset of Giant Cell Arteritis typically presents with symptoms such as headache, jaw claudication, and sometimes systemic symptoms like fever and malaise. The condition is associated with the larger vessels, and the risk of developing it significantly increases after the age of 50, making it particularly relevant in elderly populations.

In contrast, while other inflammatory conditions like rheumatoid arthritis and lupus can occur in older adults, they often have a broader demographic and can affect individuals at various ages, including younger populations. Osteoarthritis is a degenerative joint disease commonly seen in older adults but tends to be more related to wear and tear than inflammation. Thus, the age specificity and the nature of the inflammation in Giant Cell Arteritis make it the most fitting choice for a condition that primarily affects patients over the age of 50.