Which genetic disorder is characterized by a reduced ability to create blood clots?

The genetic disorder characterized by a reduced ability to create blood clots is von Willebrand Disease. This disorder is caused by a deficiency or dysfunction of von Willebrand factor (vWF), a crucial protein that helps platelets stick together and adhere to the blood vessel wall during the clotting process. Individuals with von Willebrand Disease often experience excessive bleeding, easy bruising, and prolonged bleeding after injuries due to this impaired clotting ability.

While hemophilia is also a bleeding disorder, it is primarily due to a deficiency of specific clotting factors (Factor VIII for hemophilia A and Factor IX for hemophilia B) rather than a problem with platelet function. Sickle Cell Disease and Thalassemia are primarily related to abnormal hemoglobin and red blood cell production, which impacts oxygen transport but does not directly relate to clotting ability. Therefore, von Willebrand Disease is the most accurate answer regarding reduced clotting ability due to its direct involvement with the function of platelets in the clotting cascade.