What symptom does not frequently appear in patients with Cushing's syndrome?

In patients with Cushing's syndrome, hypotension is not a commonly observed symptom. Cushing's syndrome, characterized by an excess of cortisol, typically leads to several distinct symptoms due to the effects of heightened cortisol levels on various body systems.

Moon facies, which is the rounded appearance of the face, is a classic manifestation of Cushing's syndrome and arises from fat redistribution. Muscle weakness is also frequently reported as individuals experience catabolism of muscle tissue due to elevated cortisol. Central obesity is another hallmark of Cushing's syndrome, as cortisol promotes fat accumulation, particularly in the abdominal area, leading to a distinctive body habitus.

In contrast, hypotension would generally be inconsistent with the condition. Patients with Cushing's syndrome often experience hypertension rather than low blood pressure due to the effects of cortisol on fluid retention and vascular resistance. This is why hypotension stands out as a symptom that does not align with the typical presentations of Cushing's syndrome.