What percentage of fever of unknown origin (FUO) in patients 65 and older is accounted for by Giant Cell Arteritis?

Giant Cell Arteritis (GCA), a form of vasculitis that primarily affects older adults, is known to be a significant cause of fever of unknown origin (FUO) in this age group. In patients aged 65 and older, GCA can account for approximately 15% of cases of FUO. This highlights the importance of considering GCA when evaluating older patients presenting with unexplained fever, as timely diagnosis and treatment are critical to prevent complications such as vision loss or other severe outcomes.

By understanding that a substantial proportion of FUO cases in this demographic are linked to GCA, healthcare providers can prioritize appropriate diagnostic measures, including laboratory tests and imaging studies, to investigate for this condition. This knowledge emphasizes the role of GCA in the differential diagnosis of FUO in older adults, reinforcing the need for vigilance in this population.