What is the primary treatment for Addison's disease?

The primary treatment for Addison's disease involves both glucocorticoid and mineralocorticoid replacement therapy. Addison's disease is characterized by adrenal insufficiency, where the adrenal glands do not produce sufficient hormones, particularly cortisol and aldosterone.

Glucocorticoids, such as hydrocortisone or prednisone, are essential for replacing the cortisol that the body cannot produce. This helps to manage symptoms such as fatigue, weight loss, and low blood pressure, and it also plays a critical role in the body's stress response.

On the other hand, mineralocorticoids, primarily fludrocortisone, are administered to address the deficiency in aldosterone. Aldosterone is important for regulating sodium and potassium levels and maintaining blood volume and pressure.

Together, these treatments ensure that both cortisol and aldosterone levels are adequately maintained, effectively managing the symptoms and preventing adrenal crises. This comprehensive approach directly addresses the hormonal deficiencies caused by Addison's disease, making it the cornerstone of effective management for patients with this condition.