What is the primary treatment for acetaminophen (Tylenol) intoxication?

The primary treatment for acetaminophen intoxication is N-acetylcysteine. This agent acts as a precursor to glutathione, which is important in detoxifying the harmful metabolite of acetaminophen, N-acetyl-p-benzoquinone imine (NAPQI). When acetaminophen is taken in excessive amounts, it depletes the liver's stores of glutathione and leads to liver damage. By administering N-acetylcysteine, you help restore glutathione levels, allowing for the safe metabolism of acetaminophen and thereby mitigating hepatic injury.

N-acetylcysteine is most effective when given within 8 to 10 hours after the ingestion of acetaminophen, but it can still provide benefits up to 24 hours post-ingestion in some cases. It is given intravenously or orally, depending on the severity of the overdose and the patient's condition.

In contrast, the other options do not serve as effective treatments for acetaminophen overdose. Activated charcoal may be used in certain scenarios to prevent further absorption of the drug if the administration occurs soon after ingestion, but it does not address the toxic metabolic effects of acetaminophen. Ipecac syrup is not recommended for inducing