What is the normal range for total iron-binding capacity (TIBC)?

The normal range for total iron-binding capacity (TIBC) is generally accepted to be between 250 and 450 micrograms per deciliter (µg/dL). This measurement is used to assess the blood's capacity to bind iron with transferrin, the main protein that transports iron in the bloodstream.

A TIBC value within this range is indicative of a healthy iron metabolism in the body. When interpreting TIBC results, it is important to consider them in the context of serum iron and ferritin levels, as they together provide useful information regarding a patient’s iron status—whether there is sufficient iron, an iron deficiency, or iron overload.

Understanding TIBC is particularly relevant in clinical scenarios involving anemia, where distinguishing the type (e.g., iron-deficiency anemia versus anemia of chronic disease) is crucial for effective management and treatment. The other ranges presented do not align with established clinical standards for TIBC, making the range of 250-450 µg/dL the correct choice.