What is the normal creatinine clearance (CrCl) in men under age 40?

Creatinine clearance (CrCl) is a measure of kidney function and reflects the ability of the kidneys to filter creatinine from the blood, a waste product from muscle metabolism. In healthy men under the age of 40, normal creatinine clearance values typically range from approximately 107 to 139 mL/min. This range may be influenced by factors such as muscle mass, hydration status, and age, but in the specific case of younger adult males, we observe that muscle mass is generally optimal, leading to higher CrCl levels.

The specified range of 107-139 mL/min aligns well with established clinical guidelines and studies in nephrology, reinforcing its acceptability as a standard for assessing renal function in this demographic. Understanding these values is crucial for preventing and diagnosing kidney issues, as well as adjusting medication dosing that is renally cleared. Higher or lower readings may indicate different renal pathologies and warrant further investigation, making the knowledge of normal ranges vital for any advanced practice provider.