What is considered an abnormal PSA level?

A prostate-specific antigen (PSA) level that exceeds 4 nanograms per milliliter is generally regarded as abnormal. This threshold is significant as it indicates a higher likelihood of prostate cancer, prompting further evaluation or investigation.

PSA is a protein produced by the prostate gland, and it can be elevated not only in cases of prostate cancer but also in benign conditions such as benign prostatic hyperplasia (BPH) and prostatitis. While levels between 3-4 nanograms per milliliter may be concerning and warrant monitoring, particularly in certain patient populations, they are not classified as definitively abnormal. As such, the highest level provided—over 4 nanograms per milliliter—serves as the most critical cutoff in clinical practice, indicating the need for further diagnostic procedures such as imaging or biopsy to discern the underlying cause.

In summary, a PSA level over 4 is a key indicator that can lead to significant clinical action, whereas levels below this value often do not meet criteria for immediate concern.