What is a potential side effect of prolonged use of Reglan?

Prolonged use of Reglan (metoclopramide) is associated with an increased risk of extrapyramidal symptoms (EPS). EPS are drug-induced movement disorders that can include symptoms such as tremors, rigidity, bradykinesia, and dystonic reactions. These symptoms arise due to the drug's action as a dopamine antagonist, particularly in the central nervous system. Dopamine is a key neurotransmitter involved in the regulation of motor control, and blocking its action can lead to the development of these movement disorders, especially with long-term use.

While other side effects can occur with Reglan, such as dry mouth, constipation, and weight gain, these are not uniquely related to the prolonged use of the medication or as prominently associated with the drug’s profile as EPS. The focus on EPS highlights the importance of monitoring patients who are on long-term treatment with metoclopramide, as these symptoms can significantly affect a patient's quality of life and may require dose adjustments or discontinuation of the medication.